For some neurological disorders, disease is primarily RNA mediated due to expression of non-coding microsatellite expansion RNAs (RNAexp).Toxicity is thought to result from enhanced binding of proteins to these expansions and depletion from their normal cellular Grinders targets.However, experimental evidence for this sequestration model is lacking
The informed netizen of today is in a state of information overload.With 785 million broadband subscribers and an urban and rural teledensity of 138% and 60%, respectively [1], India is already the second-largest online digital market.Today, in theory, medical journals and textbooks can be accessed by anyone, anytime, anywhere, and at affordable ra
Among the zero-knowledge succinct non-interactive arguments of knowledge (zk-SNARK), the simulation-extractable zk-SNARK (SE-SNARK) introduces a CREAM security notion of non-malleability.The existing pairing-based zk-SNARKs designed from linear encoding are known to be vulnerable to algebraic manipulation of the proof.The latest SE-SNARKs check the
This study was designed to examine the narrative language abilities of children and adolescents with Down syndrome in comparison to same-age peers with fragile X syndrome and younger typically developing children matched by nonverbal cognitive ability levels.Participants produced narrative retells from a wordless picture book.Narratives were analyz
Introduction: Due to out-of-field effects in radiation therapy, the determination and reduction of both unwanted photon and photoneutron doses are essential for the reasonable assessment of the risks to healthy tissues.Material and Methods: By the application of a multilayer shield throughout the phantom and using two models for photoneutron and ph